Investigate the nitrile functional group with Orbit molecular models. Learn about key compounds, chemical reactivity, biological roles, and more as they relate to chemical & biological applications.
Nitriles are organic compounds containing the carbon–nitrogen triple bond (–C≡N), a functional group important in both synthetic organic chemistry and biochemical contexts. In chemistry, nitriles are studied for nucleophilic addition, hydrolysis to carboxylic acids, and their role as versatile intermediates in the preparation of amides, amines, and heterocycles. In biology and medicine, nitrile-containing molecules occur in pharmaceuticals, natural products, and metabolic intermediates. Orbit nitrile molecular models allow students to visualize linear geometry, triple-bond electron density, and functional group interactions, making them valuable tools for chemistry majors and biology, nursing, or premed students.
Indigo Instruments has held inventory of genuine Cochranes of Oxford (Orbit) atoms & bonds for 30+ years. These parts are compatible with every molecular model set we have sold since day 1. This quality may appear expensive but no parts support from other vendors costs even more.
Compound | Chemistry Use Case | Biology / Medicine Relevance |
---|---|---|
Acetonitrile | Solvent and simple aliphatic nitrile for studying nucleophilic addition and hydrolysis reactions. | Used in laboratory extractions; illustrates safety considerations. |
Benzonitrile | Aromatic nitrile; demonstrates electronic effects in addition reactions and aromatic reactivity. | Present in some plant metabolites; model for bioactive aromatic nitriles. |
Cyanoalanine | Shows nitrile in amino acid derivatives; studies enzyme-mediated transformations. | Intermediate in cyanogenic metabolism; relevant for understanding detoxification. |
Rilpivirine | Pharmaceutical nitrile; illustrates structure–activity relationships in drug design. | Antiretroviral drug; demonstrates medicinal chemistry applications. |
Malononitrile | Active methylene compound; condensation reactions and Knoevenagel mechanisms. | Model for enzyme mimic studies; limited direct biological occurrence. |
The 68845NV basic set includes 16 carbons and 18 hydrogens but only 2 of the tetrahedral nitrogens (blue) and 6 of the 50mm white bonds, so only 2 of the 3 nitriles shown can be built simultaneously.
The nitrile molecular structures shown in the image are acetonitrile, acrylonitrile & cyanide shown from left to right clockwise. Build these & other alcohols with the Indigo® Instruments 3D Molecular Model Builder
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