Dimethyltryptamine

Create a 3D chemical structure model of Dimethyltryptamine out of Genuine Molymod Atoms & Bonds by Indigo

Dimethyltryptamine (DMT) is a small, naturally occurring indole alkaloid with powerful psychoactive properties. Its molecular structure includes an indole ring system (a fused benzene and pyrrole), which mimics serotonin (5-HT) and other tryptamine neurotransmitters. It has a a dimethylated ethylamine side chain, where the terminal nitrogen bears two methyl groups, enhancing lipid solubility and influencing blood-brain barrier permeability. These features place DMT structurally alongside serotonin, melatonin, and LSD, forming a key part of the tryptamine class.

DMT’s indole core is an excellent teaching model for heterocyclic aromaticity and electron delocalization. Its N,N-dimethylation provides insight into how minor structural changes can radically alter a compound’s pharmacology. Tryptamine derivatives like DMT illustrate how structure–activity relationships (SAR) influence serotonin receptor binding, particularly 5-HT2A agonism, which is central to its psychedelic effects.

Use our 3D Molecular Model Builder to compare conformational differences, electron distribution, and bonding geometries in: Tryptamine which is the metabolic backbone of DMT; Serotonin which is a key neurotransmitter with structural similarities: and Melatonin, another indole derivative involved in circadian rhythms.

A molecular model of Dimethyltryptamine in the Molymod Hybrid Dome style uses the atoms & bonds in the parts list below. Our free 3D Molecular Model Builder shows other styles & allows for image rotation as an assembly guide.